HLA-B27
Más néven:
Hivatalos név:
Humán Leukocita Antigén B27
Másnéven: 25-Hidroxi-D vitamin (Kalcidiol); 1.25 Dihidroxi-D vitamin (Kalcitriol)
012.  A cikk utoljára módosult: 27.10.2017.
Mire való a vizsgálat?

Annak meghatározására, hogy az Ön sejtjei felszínén megtalálható-e a Humán Leukocita Antigén B27 (HLA B27). Ennek kimutatása segít felmérni bizonyos – a HLA B27 jelenlétében nagyobb valószínűséggel kialakuló – autoimmun betegségek kockázatát.

Mikor kell a vizsgálatot elvégezni?

Abban az esetben indokolt elvégezni a vizsgálatot, ha az ízületi gyulladás gyanúját felvető idült ízületi fájdalom, ízületi merevség, gyulladás van jelen meghatározott testtájékokon (mint például a derék, csípő, nyak, mellkas), vagy a szem fájdalmas gyulladása (uveitisz) alakult ki – különösen akkor, ha Ön férfi és a panaszok a harmincas éveiben kezdődtek.

Milyen mintára van szükség?

A kar könyökhajlati vénájából vett vérmintára van szükség.

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Áttekintés

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Vizsgálat

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Gyakori kérdések

Mire való a vizsgálat?
Mikor kéri az orvos a vizsgálatot?
Mit jelent a vizsgálati eredmény?
Mit kell még tudnom?
Mi okozza a HLA B27-tel összefüggésbe hozható autoimmun betegségeket?
Milyen hosszú időbe telik, amíg elkészül a HLA B27 vizsgálat eredménye?
Érdemes lenne mindenkinél elvégezni a HLA B27 vizsgálatot?

Kapcsolódó oldalak

Laboratóriumi vizsgálatok
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Állapotok és betegségek
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Máshol az interneten

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Felhasznált irodalom

Aktuális áttekintésben használt források

(© 1995-2017). HLA Class I Molecular Typing Disease Association. Mayo Clinic Mayo Medical Laboratories. Available online at http://www.mayomedicallaboratories.com/test-catalog/Overview/89185. Accessed February 2017.

(© 1996-2016). HLA Matching. Be the Match. Available online at http://bethematch.org/For-Patients-and-Families/Finding-a-donor/HLA-matching/. Accessed February 2017.

Khan, M.A. (2013 October). Polymorphism of HLA-B27: 105 subtypes currently known. Current Rheumatology Reports. Available online at https://www.ncbi.nlm.nih.gov/pubmed/23990399. Accessed February 2017.

Greco, F. (Updated 2015 February 18). Histocompatibility antigen test. MedlinePlus Medical Encyclopedia. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003550.htm. Accessed February 2017.

Di Lorenzo, A. L. (Updated 2015 April 17). HLA-B27 syndromes. Medscape Reference. Available online at http://emedicine.medscape.com/article/1201027-overview. Accessed February 2017.

Starkebaum, G.A. (Reviewed 2015 April 28). HLA-B27 antigen. MedlinePlus Medical Encyclopedia. Available online at https://medlineplus.gov/ency/article/003551.htm. Accessed February 2017.

(Reviewed 2015 July). HLA-B27 antigen. Quest Diagnostics. Available online at https://www.questdiagnostics.com/testcenter/testguide.action?dc=TS_HLA-B27_Antigen. Accessed February 2017.

Malhotra, P. et. al. (Updated 2015 December 30) Immunology of Transplant Rejection. Medscape Reference. Available online at http://emedicine.medscape.com/article/432209-overview#showall. Accessed February 2017.

(© 2017). HLA Typing/Matching. UC Davis Transplant Center. Available online at http://www.ucdmc.ucdavis.edu/transplant/learnabout/learn_hla_type_match.html. Accessed February 2017.

Johns, Moloney Johns, Snyder, M. (© 2017). HLA-B27 antigen. University of Rochester Medical Center Health Encyclopedia. Available online at https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid=hla_b27_antigen. Accessed February 2017.

Korábbi áttekintések során használt források

Thomas, Clayton L., Editor (1997). Taber's Cyclopedic Medical Dictionary. F.A. Davis Company, Philadelphia, PA [18th Edition].

Pagana, Kathleen D. & Pagana, Timothy J. (2001). Mosby's Diagnostic and Laboratory Test Reference 5th Edition: Mosby, Inc., Saint Louis, MO.

Ankylosing spondylitis. Hendrick Health System, AccessMed Online Health Information Library [On-line information]. Available online at http://www.ehendrick.org/healthy/.

HLA-B27. ARUP's Guide to Clinical Laboratory Testing (CLT) [On-line information]. Available online at http://www.aruplab.com/guides/clt/tests/clt_a287.htm#1195370.

Diagnosis, Symptoms, and Treatment. Spondylitis Association of America [On-line information]. Available online at http://www.spondylitis.org/html/htmlpages.asp?load=diagnosis_what.htm.

Mayo Clinic Staff (2003 June 05). Ankylosing spondylitis. MayoClinic.com, Diseases and Conditions [On-line information. Available online at http://www.mayoclinic.com/invoke.cfm?id=DS00483.

Kovacs, B. (2001 November 29, Updated). Reiter's syndrome. MedlinePlus Health Information, Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/000440.htm.

Milone, M. (2001 November 19, Updated). Histocompatibility antigens. MedlinePlus Health Information, Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003550.htm.

Milone, M. (2001 December 5, Updated). HLA-B27 antigen. MedlinePlus Health Information, Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003551.htm.

(2003 May 21, Updated). Spondylitis: Frequently Asked Questions. Spondylitis Association of America [On-line information]. Available online at http://www.spondylitis.org/about/faq.aspx.

(2003 June 19, Updated). Reactive Arthritis/Reiter's Syndrome (ReA), Diagnosis. Spondylitis Association of America [On-line information]. Available online at http://www.spondylitis.org/about/reactive/diagnosis.aspx.

Agrawal, S. (2003 August 15). Immunophenotyping using flow cytometry. Express Healthcare Management [On-line Newspaper, India]. Available online at http://www.expresshealthcaremgmt.com/labwatch/lab6.shtml.

Waheed, N. (1998). HLA-B27 Associated Uveitis. Massachusetts Eye & Ear Infirmary, Ocular Immunology & Uveitis Service [On-line information]. Available online at http://www.uveitis.org/Enhanced/MD_info/md_hlab27.htm.

Pagana, Kathleen D. & Pagana, Timothy J. (© 2007). Mosby's Diagnostic and Laboratory Test Reference 8th Edition: Mosby, Inc., Saint Louis, MO. Pp. 544-545.

(© 2007). Ankylosing Spondylitis (AS) Diagnosis. Spondylitis Association of America [On-line information]. Available online at http://www.spondylitis.org/about/as_diag.aspx. Accessed on 9/09/07.

Alexander, D. (2007 May 29, Updated). HLA-B27 antigen. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003551.htm. Accessed on 9/09/07.

Thjodleifsson, B. et. al.(2007 July 30). Evidence of a Common Genetic Background for Ankylosing Spondylitis and Inflammatory Bowel Disease. American College of Rheumatology from Arthritis & Rheumatism 2007; (DOI:10.1002/art.22812) [On-line journal article]. Available online at http://www.rheumatology.org/press/2007/0730ankylosing.asp. Accessed on 9/09/07.

(© 2007). Ankylosing Spondylitis. American College of Rheumatology [On-line information]. Available online at http://www.rheumatology.org/public/factsheets/as.asp?aud=pat. Accessed on 9/9/07.

Waheed, N. (© 1996-2006). HLA-B27 Associated Uveitis. The Ocular Immunology and Uveitis Foundation [On-line information]. Available online at http://www.uveitis.org/medical/articles/case/hlab27.html. Accessed on 9/09/07.

Dugdale, D. (Updated 2009 May 21). HLA-B27 antigen. MedlinePlus Medical Encyclopedia [On-line information] Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003551.htm. Accessed October 2010.

Mayo Clinic Staff (2009 February 3). Ankylosing spondylitis. MayoClinic.com [On-line information] Available online at http://www.mayoclinic.com/print/ankylosing-spondylitis/DS00483/DSECTION=all&METHOD=print. Accessed October 2010.

Brent, L. and Kalagate, R. (Updated 2010 May 6). Ankylosing Spondylitis and Undifferentiated Spondyloarthropathy. eMedicine On-line information] Available online at http://emedicine.medscape.com/article/332945-overview. Accessed October 2010.

Altman, R. (Revised 2008 February). Seronegative Spondyloarthropathies (Seronegative Spondyloarthritides). Merck Manual for Healthcare Professionals [On-line information] Available online at http://www.merck.com/mmpe/sec04/ch034/ch034d.html?qt=HLA-B27&alt=sh. Accessed October 2010.

Pagana, K. D. & Pagana, T. J. (© 2007). Mosby's Diagnostic and Laboratory Test Reference 8th Edition: Mosby, Inc., Saint Louis, MO. Pp 544-545.

Waheed N. HLA-B27 associated uveitis. Ocular Immunology and Uveitis Foundations, ©2008. Available online at http://www.uveitis.org/medical/articles/case/hlab27.html. Accessed Nov 2010.

Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL eds (2005). Harrison's Principles of Internal Medicine, 16th Edition, McGraw Hill, Pp 1936-1937, 1993-1997.

MedlinePlus Medical Encyclopedia. HLA-B27 antigen. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003551.htm. Accessed June 2013.

Di Lorenzo, AL et al. HLA-B27 Syndromes. Medscape Reference. Available online at http://emedicine.medscape.com/article/1201027-overview. Accessed June 2013.

Reveille JD, Hirsch R, Dillon CF, Carroll MD, Weisman MH. The prevalence of HLA-B27 in the US: data from the US National Health and Nutrition Examination Survey, 2009. Arthritis Rheum. 2012 May;64(5):1407-11. Available online at http://www.ncbi.nlm.nih.gov/pubmed/22139851. Accessed June 2013.

MayoClinic.com. Ankylosing Spondylitis. Available online at http://www.mayoclinic.com/health/ankylosing-spondylitis/DS00483/. Accessed June 2013.

Diyarbakir E, Eyerci N, Melikoglu M, Topcu A, Pirim I. HLA B27 subtype distribution among patients with ankylosing spondylitis in eastern Turkey. Genet Test Mol Biomarkers. 2012 May;16(5):456-8. Epub 2012 Mar 21. Available online at http://www.ncbi.nlm.nih.gov/pubmed/22621386. Accessed June 2013.

Spondylitis Association of America. About Ankylosing Spondylitis. Available online at http://www.spondylitis.org/about/as.aspx. Accessed June 2013.

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